A great many professions, including the biomedical sciences, need individuals that are accomplished problem-solvers and self-directed learners. The very nature of scientific research necessitates that scientists must be self-directed learners for their entire professional life. As knowledge in a given field changes, scientists must be able to adapt to new and unexpected challenges and discoveries. Issues such as these support the development of problem-based, student-centered, self-directed programs that promote the development of problem-solving and group interaction skills and at the same time allow each and every student to experience a mode of learning tailor-made to meet each student’s individual needs. Let us engage you in how PBL plays a vital role in the preparation of tomorrow’s biomedical students and STEM workforce.