Designing small organic molecules that bind tightly to proteins is a fundamental problem in discovering new therapeutic agents. Pharmaceutical companies such as Pfizer, spend so much money on finding a molecule that binds effectively and tries this with many molecules. In this multidisciplinary stream, I will learn how to model interactions between proteins and drug-like molecules using the computer program, PyMOL. Then I will design and synthesize novel molecules that target the protein MUP-I, and then determine their binding affinities using the technique of isothermal titration calorimetry (ITC). I will learn in this stream some of the basic skills used by chemists and biologists to study protein–ligand interactions, a key step in drug discovery.