Wednesday, January 19 • 6:30pm - 8:30pm
Synthesis and Biological Recognition

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Designing small organic molecules that bind tightly to proteins is a fundamental problem in discovering new therapeutic agents. Pharmaceutical companies such as Pfizer, spend so much money on finding a molecule that binds effectively and tries this with many molecules. In this multidisciplinary stream, I will learn how to model interactions between proteins and drug-like molecules using the computer program, PyMOL. Then I will design and synthesize novel molecules that target the protein MUP-I, and then determine their binding affinities using the technique of isothermal titration calorimetry (ITC). I will learn in this stream some of the basic skills used by chemists and biologists to study protein–ligand interactions, a key step in drug discovery.


Wednesday January 19, 2011 6:30pm - 8:30pm
Glass Oaks Main Floor - Side Wing

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